Florence, the 1560s. Lucrezia, third daughter of Cosimo de' Medici, is free to wander the palazzo at will. But when her older sister dies on the eve of marriage to Alfonso d'Este, ruler of Ferrara, Modena and Reggio, Lucrezia is thrust unwittingly into the limelight when the duke requests her hand in marriage. Having barely left girlhood, Lucrezia must now make her way in a troubled court. Perhaps most mystifying of all is her husband himself, Alfonso. Is he the playful sophisticate he appears to be before their wedding, or the ruthless politician before whom even his formidable sisters seem to tremble? As Lucrezia sits in uncomfortable finery for the painting that is to preserve her image for centuries to come, one thing becomes worryingly clear. In the court's eyes, she has one duty: to provide the heir who will shore up the future of the Ferrarese dynasty. Until then, her future hangs entirely in the balance.